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MAP3K13 (LZK) Antibody (C-term)

Mouse Monoclonal Antibody (Mab)

     
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  • IF - MAP3K13 (LZK) Antibody (C-term) AM2234b
    Fluorescent image of NCI-H460 cells stained with MAP3K13 (LZK) Antibody (N-term)(Cat#AM2234B). AM2234B was diluted at 1:100 dilution. An Alexa Fluor® 488-conjugated goat anti-mouse lgM at 1:400 dilution was used as the secondary antibody (green). DAPI was used to stain the cell nuclear (blue).
  • IF - MAP3K13 (LZK) Antibody (C-term) AM2234b
    Fluorescent image of NCI-H460 cells stained with MAP3K13 (LZK) Antibody (N-term)(Cat#AM2234B). AM2234B was diluted at 1:100 dilution. An Alexa Fluor® 488-conjugated goat anti-mouse lgM at 1:400 dilution was used as the secondary antibody (green).
  • IF - MAP3K13 (LZK) Antibody (C-term) AM2234b
    Fluorescent image of NCI-H460 cells stained with MAP3K13 (LZK) Antibody (N-term)(Cat#AM2234B). AM2234B was diluted at 1:100 dilution. An Alexa Fluor® 488-conjugated goat anti-mouse lgM at 1:400 dilution was used as the secondary antibody (green). DAPI was used to stain the cell nuclear (blue). Cytoplasmic actin was counterstained with Alexa Fluor® 555 conjugated with Phalloidin (red).
  • WB - MAP3K13 (LZK) Antibody (C-term) AM2234b
    MAP3K13 (LZK) Antibody (N-term) (Cat. #AM2234b) western blot analysis in NCI-H460 cell line lysates (35μg/lane).This demonstrates the MAP3K13 (LZK) antibody detected the MAP3K13 (LZK) protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, E
Primary Accession O43283
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 810CT26.6.1.1
Calculated MW 108296 Da
Antigen Region 52-305 aa
Additional Information
Gene ID 9175
Other Names Mitogen-activated protein kinase kinase kinase 13, Leucine zipper-bearing kinase, Mixed lineage kinase, MLK, MAP3K13 (HGNC:6852)
Target/Specificity Purified His-tagged MAP3K13 protein fragment was used to produced this monoclonal antibody.
Dilution IF~~1:100
WB~~1:1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAP3K13 (LZK) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP3K13 (HGNC:6852)
Function Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein
Tissue Location Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas
Research Areas
Citations (0)

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Background

Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.

References

Ikeda A., et al. J. Biochem. 130:773-781(2001).
Masaki M., et al. Eur. J. Biochem. 270:76-83(2003).
Greenman C., et al. Nature 446:153-158(2007).
Sakuma H., et al. J. Biol. Chem. 272:28622-28629(1997).
Ota T., et al. Nat. Genet. 36:40-45(2004).

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$ 295.00
$ 99.00
Cat# AM2234b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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