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Gab1 AntibodyMouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AM3111a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
Gab1 Antibody - Product info | |
| Application | WB
|
| Primary Accession | Q13480 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Mouse IgG1 |
| Clone Names | 1AT1979 |
| Calculated MW | 76616 Da |
Gab1 Antibody - Additional info | |
| Gene ID 2549 | |
| Other Names GAB1; GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1 | |
| Target/Specificity This Gab1 antibody is generated from mice immunized with a GST fusion protein encoding full length human GAB1. | |
| Dilution WB~~1:1000 | |
| Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Gab1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Gab1 Antibody - Protein Information | |
| Name GAB1 | |
| Function Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) | |
Gab1 Antibody - Related products
AP3108a: Phospho-Gab1-Y654 Antibody
AP3109a: Phospho-Gab1-Y627 Antibody
AP3109b: Phospho-Gab1-Y627 Antibody
AP3110a: Gab1 Mutant Y659 Antibody
AP3302b: Phospho-Gab1-Y659 Antibody
AP3599a: Phospho-GAB1-pY259 Antibody
DC08452: Human GAB1 cDNA Clone
BP3108a: Phospho-Gab1-Y654 Antibody Blocking Peptide
BP3109a: Phospho-Gab1-Y627 Antibody Blocking Peptide
BP3109b: Phospho-Gab1-Y627 Antibody Blocking Peptide
BP3110a: Gab1 Mutant Y659 Antibody Blocking Peptide
BP3302b: Phospho-Gab1-Y659 Antibody Blocking Peptide
BP3599a: Phospho-GAB1-pY259 Antibody Blocking Peptide
BP7832b: GAB1 Antibody (Y627) Blocking Peptide
Gab1 Antibody - Application data
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Wild-type (+/+) and Gab1-/- (-/-) cells were heat shocked (HS) at 42掳C for 1 h or irradiated with UV-B light (400 J/m2) and then incubated at 37? for 1 h. Cell lysates were prepared and subjected to immunoprecipitation (IP) with an anti-JNK2 antibody. The immunoprecipitates were resolved by SDS- PAGE and immunoblotted (IB) with anti-Gab1 antibody. Data courtesy of Dr. GS Feng at The Burnham Institute.
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Rescue of the JNK pathway by expression of wild-type Gab1 in Gab1-/- cells. Gab1-/- cells were transiently transfected with 1, 2, or 4 of the expression construct for human Gab1 cDNA, using the GenePORTER 2 transfection reagent (Gene Therapy Systems Inc.). After incubation, the cells were irradiated with UV-B light at 400 J/m2 or left untreated. Exogenous expression of Gab1 in transfected cells was confirmed by anti-Gab1 immunoblot analysis with wild-type cells as positive control. +/+, wild-type cells; -/-, Gab1-/- cells. (Mol. Cell. Biol. 2004 Feb 15;24(4):1531-1539)
Gab1 Antibody - Research Areas
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BACKGROUND
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
REFERENCES
An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014. Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086. Grb2-associated binder 1 (Gab1) genetic polymorphism, Helicobacter pylori infection, and chronic atrophic gastritis among older adults from Germany. Gao L, et al. Mol Carcinog, 2010 Oct. PMID 20602450. New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496. Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric control. McDonald CB, et al. Arch Biochem Biophys, 2010 Feb 15. PMID 20005866.
