|Application ||IHC-P, WB, E|
|Calculated MW||24722 Da|
|Other Names||Superoxide dismutase [Mn], mitochondrial, SOD2|
|Target/Specificity||Purified His-tagged SOD protein(Fragment) was used to produced this monoclonal antibody.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SOD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|
|Cellular Location||Mitochondrion matrix.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
The sequence polymorphism of MnSOD gene in subjects with respiratory insufficiency in COPD. Pietras T, et al. Med Sci Monit, 2010 Aug 7. PMID 20802415.
Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus. Jones DA, et al. Diabetes Res Clin Pract, 2010 Aug 20. PMID 20728955.
Assessing oxidative pathway genes as risk factors for bipolar disorder. Fullerton JM, et al. Bipolar Disord, 2010 Aug. PMID 20712757.
Do genetic variations in antioxidant enzymes influence the course of hereditary hemochromatosis? Nahon P, et al. Antioxid Redox Signal, 2010 Aug 1. PMID 20673159.
Manganese superoxide dismutase versus p53: the mitochondrial center. Holley AK, et al. Ann N Y Acad Sci, 2010 Jul. PMID 20649542.
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