|Application ||WB, E|
|Calculated MW||19535 Da|
|Other Names||Protein tyrosine phosphatase type IVA 3, PRL-R, Protein-tyrosine phosphatase 4a3, Protein-tyrosine phosphatase of regenerating liver 3, PRL-3, PTP4A3, PRL3|
|Target/Specificity||This monoclonal antibody is generated from mice immunized with a recombinant protein.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRL3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.|
|Cellular Location||Cell membrane. Early endosome|
|Tissue Location||Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.
PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase. Wang H, et al. Cancer Cell, 2010 Jul 13. PMID 20609352.
Constitutive suppression of PRL-3 inhibits invasion and proliferation of gastric cancer cell in vitro and in vivo. Matsukawa Y, et al. Pathobiology, 2010. PMID 20516731.
Prognostic and metastatic value of phosphatase of regenerating liver-3 in invasive breast cancer. Hao RT, et al. J Cancer Res Clin Oncol, 2010 Sep. PMID 20140626.
Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2. Min SH, et al. Life Sci, 2010 Jan 2. PMID 19945467.
PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin beta1-ERK1/2 and-MMP2 signaling. Peng L, et al. Mol Cancer, 2009 Nov 24. PMID 19930715.
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