|Application ||IHC-P, WB, E|
|Calculated MW||27992 Da|
|Antigen Region||1-246 aa|
|Other Names||B-cell receptor-associated protein 31, BCR-associated protein 31, Bap31, 6C6-AG tumor-associated antigen, Protein CDM, p28, BCAP31, BAP31, DXS1357E|
|Target/Specificity||This BAP31 antibody is generated from a mouse immunized with a recombinant.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BAP31 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8- mediated apoptosis.|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Note=May shuttle between the ER and the intermediate compartment/cis-Golgi complex|
|Tissue Location||Ubiquitous. Highly expressed in neurons and discrete endocrine cells.|
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Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8- mediated apoptosis.
Mosser J.,et al.Genomics 22:469-471(1994).
Li E.,et al.Eur. J. Biochem. 238:631-638(1996).
Adachi T.,et al.EMBO J. 15:1534-1541(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ross M.T.,et al.Nature 434:325-337(2005).
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