|Application ||FC, WB, E|
|Calculated MW||24868 Da|
|Other Names||Ras-related protein Rab-27A, Rab-27, GTP-binding protein Ram, RAB27A, RAB27|
|Target/Specificity||This RAB27A antibody is generated from a mouse immunized with a recombinant protein of human RAB27A.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RAB27A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.|
|Cellular Location||Membrane; Lipid-anchor. Melanosome. Late endosome. Lysosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). Localizes to endosomal exocytic vesicles (PubMed:17237785).|
|Tissue Location||Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.|
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Provided below are standard protocols that you may find useful for product applications.
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
Seabra M.C.,et al.J. Biol. Chem. 270:24420-24427(1995).
Seabra M.C.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Chen D.,et al.Biochem. Mol. Med. 60:27-37(1997).
Tolmachova T.,et al.Gene 239:109-116(1999).
Hu R.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
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