|Application ||WB, E|
|Calculated MW||158298 Da|
|Other Names||Protein LAP2, Densin-180-like protein, Erbb2-interacting protein, Erbin, ERBB2IP, ERBIN, KIAA1225, LAP2|
|Target/Specificity||This LAP2 antibody is generated from a mouse immunized with a recombinant protein of human LAP2.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LAP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).|
|Cellular Location||Cell junction, hemidesmosome Nucleus membrane. Basolateral cell membrane. Note=Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity).|
|Tissue Location||Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine|
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Provided below are standard protocols that you may find useful for product applications.
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state.
Borg J.-P.,et al.Nat. Cell Biol. 2:407-414(2000).
Favre B.,et al.J. Biol. Chem. 276:32427-32436(2001).
Nagase T.,et al.DNA Res. 6:337-345(1999).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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