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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LAP2 Antibody   

LAP2 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
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  • WB - LAP2 Antibody AM8519b
    All lanes : Anti-LAP2 Antibody at 1:500-1:1000 dilution Lane 1: Hela whole cell lysate Lane 2: SW480 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 158 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - LAP2 Antibody AM8519b
    All lanes : Anti-LAP2 Antibody at 1:1000-1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: HepG2 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 158 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q96RT1
Reactivity Human
Host Mouse
Clonality monoclonal
Isotype IgG1,k
Clone Names 1617CT859.9.32
Calculated MW 158298 Da
Additional Information
Gene ID 55914
Other Names Protein LAP2, Densin-180-like protein, Erbb2-interacting protein, Erbin, ERBB2IP, ERBIN, KIAA1225, LAP2
Target/Specificity This LAP2 antibody is generated from a mouse immunized with a recombinant protein of human LAP2.
Dilution WB~~1:1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLAP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ERBIN {ECO:0000303|PubMed:10878805}
Function Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).
Cellular Location Cell junction, hemidesmosome Nucleus membrane. Basolateral cell membrane. Note=Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity).
Tissue Location Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine
Research Areas
Citations (0)

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Background

Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state.

References

Borg J.-P.,et al.Nat. Cell Biol. 2:407-414(2000).
Favre B.,et al.J. Biol. Chem. 276:32427-32436(2001).
Nagase T.,et al.DNA Res. 6:337-345(1999).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 295.00
$ 99.00
Cat# AM8519b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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