|Application ||FC, WB, E|
|Calculated MW||50408 Da|
|Other Names||Protein C-ets-1, p54, ETS1, EWSR2|
|Target/Specificity||This ETS1 antibody is generated from a mouse immunized with a recombinant protein of human ETS1.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ETS1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.|
|Cellular Location||Cytoplasm. Nucleus. Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27|
|Tissue Location||Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.|
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Provided below are standard protocols that you may find useful for product applications.
Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
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Watson D.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:7862-7866(1988).
Laitem C.,et al.Oncogene 28:2087-2099(2009).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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