|Application ||WB, E|
|Calculated MW||192948 Da|
|Other Names||Protein polybromo-1, hPB1, BRG1-associated factor 180, BAF180, Polybromo-1D, PBRM1, BAF180, PB1|
|Target/Specificity||This PBRM1 antibody is generated from a mouse immunized with a recombinant proteinof human PBRM1.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PBRM1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation.|
|Tissue Location||Widely expressed.|
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Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.
Xue Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:13015-13020(2000).
Horikawa I.,et al.DNA Seq. 13:211-215(2002).
Sekine I.,et al.Oncogene 24:2735-2738(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Lemon B.,et al.Nature 414:924-928(2001).
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