|Application ||FC, WB, E|
|Calculated MW||83166 Da|
|Other Names||Glycine--tRNA ligase, 188.8.131.52, Diadenosine tetraphosphate synthetase, AP-4-A synthetase, Glycyl-tRNA synthetase, GlyRS, GARS|
|Target/Specificity||This GARS antibody is generated from a mouse immunized with a recombinant protein between 35-305 amino acids from human GARS.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GARS Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs.|
|Cellular Location||Cytoplasm. Mitochondrion. Cell projection, axon Note=Associated with granules in cultured neuron cells|
|Tissue Location||Widely expressed, including brain and spinal cord.|
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Provided below are standard protocols that you may find useful for product applications.
Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs.
Shiba K.,et al.J. Biol. Chem. 269:30049-30055(1994).
Williams J.H.,et al.Nucleic Acids Res. 23:1307-1310(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 424:157-164(2003).
Ge Q.,et al.J. Biol. Chem. 269:28790-28797(1994).
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