|Application ||WB, E|
|Calculated MW||44565 Da|
|Other Names||Serpin B3, Protein T4-A, Squamous cell carcinoma antigen 1, SCCA-1, SERPINB3, SCCA, SCCA1|
|Target/Specificity||This antibody is generated from a mouse immunized with a recombinant between 1-390 amino acids from human.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SERPINB3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).|
|Cellular Location||Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level|
|Tissue Location||Squamous cells. Expressed in some hepatocellular carcinoma (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).
Suminami Y.,et al.Biochem. Biophys. Res. Commun. 181:51-58(1991).
Schneider S.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:3147-3151(1995).
Suminami Y.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Moore P.L.,et al.J. Biol. Chem. 278:46709-46717(2003).
Tong C.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
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