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CBFA2T3 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • WB - CBFA2T3 Antibody AM8576b
    All lanes : Anti-CBFA2T3 Antibody at 1:1000-1:2000 dilution Lane 1: Jurkat whole cell lysate Lane 2: CCRF-CEM whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 71 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - CBFA2T3 Antibody AM8576b
    All lanes : Anti-CBFA2T3 Antibody at 1:500-1:2000 dilution Lane 1: HL-60 whole cell lysate Lane 2: MOLT-4 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 71 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O75081
Reactivity Human
Host Mouse
Clonality monoclonal
Isotype IgG1,k
Clone Names 1719CT425.37.65
Calculated MW 71192 Da
Additional Information
Gene ID 863
Other Names Protein CBFA2T3, MTG8-related protein 2, Myeloid translocation gene on chromosome 16 protein, hMTG16, Zinc finger MYND domain-containing protein 4, CBFA2T3, MTG16, MTGR2, ZMYND4
Target/Specificity This CBFA2T3 antibody is generated from a mouse immunized with a recombinant protein between 418-653 amino acids from human CBFA2T3.
Dilution WB~~1:500-1:2000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCBFA2T3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBFA2T3
Synonyms MTG16, MTGR2, ZMYND4
Function Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665).
Cellular Location Isoform 1: Nucleus, nucleolus. Note=The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm
Tissue Location Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level).
Citations (0)

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Background

Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation.

References

Gamou T.,et al.Blood 91:4028-4037(1998).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Calabi F.,et al.Genomics 52:332-341(1998).
Salomon-Nguyen F.,et al.Leukemia 14:1704-1705(2000).
La Starza R.,et al.Haematologica 86:212-213(2001).

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$ 295.00
$ 99.00
Cat# AM8576b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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