|Application ||WB, E|
|Calculated MW||141523 Da|
|Other Names||Multidrug resistance protein 3, 188.8.131.52, ATP-binding cassette sub-family B member 4, P-glycoprotein 3, ABCB4, MDR3, PGY3|
|Target/Specificity||This ABCB4 antibody is generated from a mouse immunized with a recombinant protein of human ABCB4.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ABCB4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.
van der Bliek A.M.,et al.Gene 71:401-411(1988).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Smit J.J.,et al.Biochim. Biophys. Acta 1261:44-56(1995).
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