|Application ||WB, E|
|Calculated MW||29280 Da|
|Other Names||Folate receptor beta, FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP, FOLR2|
|Target/Specificity||This FOLR2 antibody is generated from a mouse immunized with a recombiant protein from human FOLR2.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FOLR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Secreted|
|Tissue Location||Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues|
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Provided below are standard protocols that you may find useful for product applications.
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
Page S.T.,et al.J. Mol. Biol. 229:1175-1183(1993).
Ratnam M.,et al.Biochemistry 28:8249-8254(1989).
Sadasivan E.,et al.J. Biol. Chem. 269:4725-4735(1994).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Freisheim J.H.,et al.Adv. Enzyme Regul. 29:13-26(1989).
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