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FOLR2 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P14207 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2b,κ |
| Clone/Animal Names | 1905CT501.41.76 |
| Calculated MW | 29280 Da |
| Gene ID | 2350 |
|---|---|
| Other Names | Folate receptor beta, FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP, FOLR2 |
| Target/Specificity | This FOLR2 antibody is generated from a mouse immunized with a recombiant protein from human FOLR2. |
| Dilution | WB~~1:1000-1:2000 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FOLR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FOLR2 |
|---|---|
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Secreted |
| Tissue Location | Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues |
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
References
Page S.T.,et al.J. Mol. Biol. 229:1175-1183(1993).
Ratnam M.,et al.Biochemistry 28:8249-8254(1989).
Sadasivan E.,et al.J. Biol. Chem. 269:4725-4735(1994).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Freisheim J.H.,et al.Adv. Enzyme Regul. 29:13-26(1989).
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