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Phospho-Ser892 GABAB Receptor, R2-Subunit Antibody

Affinity purified rabbit polyclonal antibody

  • WB - Phospho-Ser892 GABAB Receptor, R2-Subunit Antibody AN1011
    Western blots of (A) Cos-7 cells transiently expressing GABABR2S892A (lane 1), wild type GABABR2 (lane 2) or control untransfected cells (lane 3). Blots were then immunolabeled with Rabbit Anti-Phospho Ser892 (Figure A). In Figure B the membrane was pre-treated with λ-Ptase (1200 units for 30 min) before being exposed to the anti-Ser892 GABAB receptor, R2-subunit antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O88871
Reactivity Rat
Predicted Bovine, Chicken, Human, Mouse, Monkey, Xenopus, Zebrafish
Host Rabbit
Clonality polyclonal
Calculated MW 110 KDa
Additional Information
Gene ID 83633
Gene Name GABBR2
Other Names Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51, Gabbr2, Gpr51
Target/Specificity Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser892 conjugated to KLH.
Dilution WB~~ 1:1000
Format Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns
Antibody Specificity Specific for the ~110k GABAB receptor, R2-subunit protein phosphorylated at Ser892.Quality Control
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-Ser892 GABAB Receptor, R2-Subunit Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Research Areas
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Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Moss and colleagues (Couve, et al., 2002) recently demonstrated that the functional coupling of GABAB R1/GABAB R2 receptors to inwardly rectifying K+ channels rapidly desensitizes. This effect is alleviated after direct phosphorylation of a single serine residue (Ser892) in the cyto-plasmic tail of GABAB R2 by cyclic AMP (cAMP)-dependent protein kinase (PKA). In addition to it’s postsynaptic effects GABAB receptors localized to the presynaptic region ave been reported to restrict the availability of synaptic vesicles for release (Sakaba and Neher, 2003).


Couve A, Thomas P, Calver AR, Hirst WD, Pangalos MN, Walsh FS, Smart TG, Moss SJ (2002) Cyclic AMP-dependent protein kinase phosphorylation facilitates GABAB receptor-effector coupling. Nat Neurosci 5:415-424.
Sakaba T, Neher E (2003) Direct modulation of synaptic vesicle priming by GABAB receptor activation at a glutamatergic synapse. Nature (London) 424:775-778.

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$ 335.00
Cat# AN1011
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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