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Phospho-Ser181 TAO2 Antibody

Affinity purified rabbit polyclonal antibody

  • WB - Phospho-Ser181 TAO2 Antibody AN1028
    Western blot of rat cortex lysate showing specific immunolabeling of the ~120k TAO2 phosphorylated at Ser181 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: λ-Ptase). The blot is identical to the control except that it was incubated in λ-Ptase (1200 units for 30 min) before being exposed to the Ser181 TAO2 antibody. The immunolabeling is completely eliminated by treatment with λ-Ptase.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UL54
Reactivity Human, Mouse, Rat
Predicted Xenopus, Zebrafish
Host Rabbit
Clonality polyclonal
Calculated MW 120 KDa
Additional Information
Gene ID 9344
Gene Name TAOK2
Other Names Serine/threonine-protein kinase TAO2, Kinase from chicken homolog C, hKFC-C, Prostate-derived sterile 20-like kinase 1, PSK-1, PSK1, Prostate-derived STE20-like kinase 1, Thousand and one amino acid protein kinase 2, TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Target/Specificity Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser181 conjugated to KLH.
Dilution WB~~ 1:1000
Format Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
Antibody Specificity Specific for the ~120k TAO2 phosphorylated at Ser181in Western blots.Immunolabeling is completely eliminated by treatment withλphosphatase.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-Ser181 TAO2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Research Areas
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In vitro , TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEKs) 3, 4, and 6 toward thei r substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999; Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonists to the stress-responsive p38 MAPKs (Chen et al., 2003). Autophos phorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser 181 is located within this domain.


Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH
(2003) TAO (thousand-a
nd-one amino acid) protein
kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. J
Biol Chem 278:22278-22283.
Chen Z, Cobb, MH (2001) Regulation of stress-responsi
ve mitogen-activated protein (MAP) kinase pathways by
TAO2. J Biol Chem 276:16070-16075.
Chen Z, Hutchison M, Cobb MH (1999) Isolation of the pr
otein kinase TAO2 and identificat
ion of its mitogen-activated
protein kinase/extracellular signal-regulated kinase ki
nase binding domain. J Biol Chem 274:28803-28807.

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$ 335.00
Cat# AN1028
(40 western blots)
Availability: 7-10 days
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