|Reactivity||Human, Mouse, Rat|
|Calculated MW||120 KDa|
|Other Names||Serine/threonine-protein kinase TAO2, Kinase from chicken homolog C, hKFC-C, Prostate-derived sterile 20-like kinase 1, PSK-1, PSK1, Prostate-derived STE20-like kinase 1, Thousand and one amino acid protein kinase 2, TAOK2, KIAA0881, MAP3K17, PSK, PSK1|
|Target/Specificity||Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser181 conjugated to KLH.|
|Format||Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.|
|Antibody Specificity||Specific for the ~120k TAO2 phosphorylated at Ser181in Western blots.Immunolabeling is completely eliminated by treatment withλphosphatase.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-Ser181 TAO2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
In vitro , TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEKs) 3, 4, and 6 toward thei r substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999; Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonists to the stress-responsive p38 MAPKs (Chen et al., 2003). Autophos phorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser 181 is located within this domain.
Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH
(2003) TAO (thousand-a
nd-one amino acid) protein
kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. J
Biol Chem 278:22278-22283.
Chen Z, Cobb, MH (2001) Regulation of stress-responsi
ve mitogen-activated protein (MAP) kinase pathways by
TAO2. J Biol Chem 276:16070-16075.
Chen Z, Hutchison M, Cobb MH (1999) Isolation of the pr
otein kinase TAO2 and identificat
ion of its mitogen-activated
protein kinase/extracellular signal-regulated kinase ki
nase binding domain. J Biol Chem 274:28803-28807.
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