|Reactivity||Bovine, Human, Mouse, Rat|
|Calculated MW||120/160 KDa|
|Other Names||Sodium/calcium exchanger 1, Na(+)/Ca(2+)-exchange protein 1, Solute carrier family 8 member 1, Slc8a1, Ncx1|
|Target/Specificity||Fusion protein from the N-terminal region of rabbit renal NaCX.|
|Format||Prepared by affinity purification using a protein G column.|
|Antibody Specificity||Specific for the ~120k and 160k Na+/Ca2+exchanger 1 protein.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Sodium Calcium Exchanger 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Ca 2+ plays a critical role in intracellular signaling and thus regulation of calcium balance is critical for the maintenance of this signaling function. The plasma membrane Na + /Ca 2+ (NaCX) exchangers mediate Na + -dependent Ca 2+ efflux in a wide variety of cell types. NaCX can move Ca 2+ either into or out of cells, depending on the net Na + , Ca 2+ , and K + gradient across the membrane. In mammals, at least 5 distinct genes code for the exchangers: Three NaCX (NaCX-1, NaCX-2, an d NaCX-3), and two in the NaCKX family (NaCKX-1 and NaCKX-2). NaCX-1 is most prominently expressed in the heart where it plays a major role in excitation-contraction coupling (Matsuoka et al., 1993). NACX-1 may also be a target for protection of the heart and brain from ischemia and reperfusion injury (Hagihara et al., 2005; Bano et al., 2005; Choi, 2005).
Bano D, Young KW, Guerin CJ, Lefeuvre R, Rothwell NJ, Na
ldini L, Rizzuto R, Carafoli E, Nicotera P (2005)
Cleavage of the plasma membrane Na
exchanger in excitotoxicity. Cell 120:275-285.
Choi DW (2005) Neurodegeneration: cellular defences destroyed. Nature 433:696-698.
Hagihara H, Yoshikawa Y, Ohga Y, Takenaka C,
Murata KY, Taniguchi S, Takaki M (2005) Na
inhibition protects the rat heart from ischemia-reperfusion
injury by blocking energy-wasting processes. Am J
Physiol Heart Circ Physiol 288:H1699-H1707.
Matsuoka S, Nicoll DA, Reilly RF, Hilgemann DW, Philipson KD
(1993) Initial localization of
regulatory regions of the
cardiac sarcolemmal Na
exchanger. Proc Natl Acad Sci USA 90:3870-3874.
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