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Sodium Calcium Exchanger 1 Antibody

Affinity purified mouse monoclonal antibody

  • WB - Sodium Calcium Exchanger 1  Antibody AN1058
    Western blot of various tissues showing specific immunolabeling of the ~120k and ~160k NaCX-1 protein. Lane 1 - Brain; Lane 2 - Heart; Lane 3 - Kidney; Lane 4 - Lung; Lane 5 - Spleen.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q01728
Reactivity Bovine, Human, Mouse, Rat
Host Mouse
Clonality monoclonal
Isotype IgG2b
Clone Names 6H2
Calculated MW 120/160 KDa
Additional Information
Gene ID 29715
Gene Name SLC8A1
Other Names Sodium/calcium exchanger 1, Na(+)/Ca(2+)-exchange protein 1, Solute carrier family 8 member 1, Slc8a1, Ncx1
Target/Specificity Fusion protein from the N-terminal region of rabbit renal NaCX.
Dilution WB~~ 1:1000
Format Prepared by affinity purification using a protein G column.
Antibody Specificity Specific for the ~120k and 160k Na+/Ca2+exchanger 1 protein.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSodium Calcium Exchanger 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ShippingBlue Ice
Research Areas
Citations (0)

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Ca 2+ plays a critical role in intracellular signaling and thus regulation of calcium balance is critical for the maintenance of this signaling function. The plasma membrane Na + /Ca 2+ (NaCX) exchangers mediate Na + -dependent Ca 2+ efflux in a wide variety of cell types. NaCX can move Ca 2+ either into or out of cells, depending on the net Na + , Ca 2+ , and K + gradient across the membrane. In mammals, at least 5 distinct genes code for the exchangers: Three NaCX (NaCX-1, NaCX-2, an d NaCX-3), and two in the NaCKX family (NaCKX-1 and NaCKX-2). NaCX-1 is most prominently expressed in the heart where it plays a major role in excitation-contraction coupling (Matsuoka et al., 1993). NACX-1 may also be a target for protection of the heart and brain from ischemia and reperfusion injury (Hagihara et al., 2005; Bano et al., 2005; Choi, 2005).


Bano D, Young KW, Guerin CJ, Lefeuvre R, Rothwell NJ, Na
ldini L, Rizzuto R, Carafoli E, Nicotera P (2005)
Cleavage of the plasma membrane Na
exchanger in excitotoxicity. Cell 120:275-285.
Choi DW (2005) Neurodegeneration: cellular defences destroyed. Nature 433:696-698.
Hagihara H, Yoshikawa Y, Ohga Y, Takenaka C,
Murata KY, Taniguchi S, Takaki M (2005) Na
inhibition protects the rat heart from ischemia-reperfusion
injury by blocking energy-wasting processes. Am J
Physiol Heart Circ Physiol 288:H1699-H1707.
Matsuoka S, Nicoll DA, Reilly RF, Hilgemann DW, Philipson KD
(1993) Initial localization of
regulatory regions of the
cardiac sarcolemmal Na
exchanger. Proc Natl Acad Sci USA 90:3870-3874.

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$ 335.00
Cat# AN1058
Availability: 7-10 days
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