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Tryptophan Hydroxylase Antibody

Affinity purified sheep polyclonal antibody

  • WB - Tryptophan Hydroxylase Antibody AN1060
    Western blot of human dorsal Raphe nucleus showing specifc immunolabeling of the ~55k tryptophan hydroxylase protein.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P17290
Reactivity Human, Rat
Host Sheep
Clonality polyclonal
Calculated MW 55 KDa
Additional Information
Gene ID 100101558
Gene Name TPH1
Other Names Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1, TPH1, TPH
Target/Specificity Recombinant rabbit tryptophan hydroxylase, isolated as inclusion bodies from E. coli and purified by preparative SDS-PAGE.
Dilution WB~~ 1:1000
Format Prepared from sheep serum by affinity purification using a column to which the recombinant protein was coupled.
Antibody Specificity Specific for the ~55k tryptophan hydroxylase protein.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTryptophan Hydroxylase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ShippingBlue Ice
Research Areas
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Tryptophan hydroxylase (TPH) catalyzes the first step in the biosynthesis of serotonin and melatonin (Martinez et al., 2001). Thus, expression of TPH can be used as an indicator of the localization of serotonin and melatonin in brain. In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland (Haycock et al., 2002) . Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis (Martinez et al., 2001).


Haycock JW, Kumer SC, Lewis DA, Vrana KE, Stockmeier CA (2002) A monoclonal antibody to tryptophan
hydroxylase: applications and identification of the epitope. J Neurosci Methods 114:205-212.
Martinez A, Knappskog PM, Haavik J (2001) A structural approach into human tryptophan hydroxylase and its
implications for the regulation of serotonin biosynthesis. Curr Med Chem 8:1077-1091.

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$ 335.00
Cat# AN1060
(40 western blots)
Availability: 7-10 days
Bulk Size
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