Phospho-Ser535,539 Interferon-α Receptor, Type I, Subunit I Antibody
Affinity purified rabbit polyclonal antibody
|Predicted||Bovine, Human, Mouse, Monkey|
|Calculated MW||110-130 KDa|
|Other Names||Interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1, IFNAR1, IFNAR|
|Target/Specificity||Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser535/539 conjugated to KLH.|
|Format||Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.|
|Antibody Specificity||Specific for IFNAR1 protein phosphorylated at Ser535,539. Note: themolecular weight of the IFNAR1 varies with cell line (different levels of glycosylation) in 293 andHeLa Cells; the mature form is ~110 - 130k.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-Ser535,539 Interferon-α Receptor, Type I, Subunit I Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron, 2001; Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-α Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).
Biron CA (2001) Interferons alpha and beta as immune regulators--a new look. Immunity 14:661-664.
Kirkwood J (2002) Cancer immunotherapy: the interferon-alpha experience. Semin Oncol 29:18-26.
Kumar KG, Tang W, Ravindranath AK, Clark WA, Croze E, Fuchs SY (2003) SCF(HOS) ubiquitin ligase mediates the
ligand-induced down-regulation of the interferon-alpha receptor. EMBO J 22:5480-5490.
K. G. Suresh Kumar, John J. Krolewski, and Serge Y. Fuchs (2004) Phosphorylation and Specific Ubiquitin Acceptor
Sites Are Required for Ubiquitination and Degradation of the IFNAR1 Subunit of Type I Interferon Receptor. J.
Biol. Chem., Nov 2004; 279: 46614 - 46620.
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