Phospho-Ser503 Kv3.1, Voltage-Gated, Potassium Channel Antibody
Affinity purified rabbit polyclonal antibody
|Calculated MW||100 KDa|
|Other Names||Potassium voltage-gated channel subfamily C member 1, NGK2, RAW2, Voltage-gated potassium channel subunit Kv31, Voltage-gated potassium channel subunit Kv4, Kcnc1|
|Target/Specificity||Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser503 conjugated to KLH.|
|Format||Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.|
|Antibody Specificity||Specific for the ~100k Kv3.1 voltage-gated potassium channel proteinphosphorylated at Ser503.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-Ser503 Kv3.1, Voltage-Gated, Potassium Channel Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999).
Blaine JT, Ribera AB (1998) Heteromultimeric potassium channels formed by members of the Kv2 subfamily. J
Burger C, Ribera AB (1996) Xenopus spinal neurons express Kv2 potassium channel transcripts during embryonic
development. J Neurosci 16:1412-1421.
Gan L, Hahn SJ, Kaczmarek LK (1999) Cell type-specific expression of the Kv3.1 gene is mediated by a negative
element in the 5' untranslated region of the Kv3.1 promoter. J Neurochem 73:1350-1362.
Maletic-Savatic M, Lenn NJ, Trimmer JS (1995) Differential spatiotemporal expression of K+ channel polypeptides in
rat hippocampal neurons developing in situ and in vitro. J Neurosci 15:3840-3851.
Pongs O (1999) Voltage-gated potassium channels: from hyperexcitability to excitement. FEBS Lett 452:31-35.
von Hehn CA, Bhattacharjee A, Kaczmarek LK (2004) Loss of Kv3.1 tonotopicity and alterations in cAMP response
element-binding protein signaling in central auditory neurons of hearing impaired mice. J Neurosci 24:1936-1940.
Ping Song and Leonard K. Kaczmarek (2006) Modulation of Kv3.1b Potassium Channel Phosphorylation in Auditory
Neurons by Conventional and Novel Protein Kinase C IsozymesJ. Biol. Chem., Jun
2006; 281: 15582 - 15591
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