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Phospho-Ser33,37 β-Catenin Antibody

Affinity purified rabbit polyclonal antibody

  • WB - Phospho-Ser33,37 β-Catenin Antibody AN1073
    Western blot of human embryonic kidney cell (HEK) lysate showing specific immunolabeling of the ~83k β-catenin phosphorylated at Ser33 and Ser37 (Upper Panel) and a pan β-catenin (Lower Panel). Control is a standard HEK cell lysate. GSK3 is a HEK cell lysate with glycogen synthase kinase 3β knocked down by SiRNA.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P35222
Reactivity Human
Predicted Mouse, Rat, Xenopus
Host Rabbit
Clonality polyclonal
Calculated MW 83 KDa
Additional Information
Gene ID 1499
Gene Name CTNNB1
Other Names Catenin beta-1, Beta-catenin, CTNNB1, CTNNB
Target/Specificity Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser33/37 conjugated to KLH.
Dilution WB~~ 1:1000
Format Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
Antibody Specificity Specific for the ~83k β-catenin phosphorylated at Ser33 and Ser37
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-Ser33,37 β-Catenin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ShippingBlue Ice
Research Areas
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β-catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway (Ding and Dale, 2002; Polakis, 2000). The role of β-catenin in these processes is thought regulated by the sequential phosphorylation of Ser29 Ser33, Ser37 and Thr41 by glycogen synthase kinase 3β (GSK3β) (Liu et al., 2002). This hyperphosphorylation promotes the ubiquitylation and targeted destruction of β-catenin. Mutations in components of this phosphorylation regulated process that prevent β-catenin hyperphosphorylation by GSK3β are trongly associated with cancers (Wang et al., 2003; Polakis, 2000; Liu et al., 2002).


Ding Y, Dale, T (2002) Wnt signal transduction: kinase cogs in a nano-machine? Trends Biochem Sci 27:327-329.
Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X (2002) Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108:837-847.
Polakis P (2000) Wnt signaling and cancer. Genes Dev 14:1837-1851.
Wang ZH, Vogelstein B, Kinzler KW (2003) Phosphorylation of β-catenin at S33, S37, or T41 can occur in the absence of phosphorylation at T45 in colon cancer cells. Cancer Res 63:5234-5235.

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$ 335.00
Cat# AN1073
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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