|Predicted||Bovine, Chicken, Mouse, Rat|
|Calculated MW||90 KDa|
|Other Names||Ribosomal protein S6 kinase alpha-2, S6K-alpha-2, 90 kDa ribosomal protein S6 kinase 2, p90-RSK 2, p90RSK2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, MAPKAP kinase 1c, MAPKAPK-1c, Protein-tyrosine kinase Mpk-9, Ribosomal S6 kinase 3, RSK-3, pp90RSK3, Rps6ka2, Mapkapk1c, Rsk3|
|Target/Specificity||Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.|
|Format||Prepared from rabbit serum by affinity purification via chromatography on an affinity column made with the C-terminal peptide used as antigen.|
|Antibody Specificity||Specific for ~90k RSK2 protein.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Ribosomal S6 Kinase 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The p90 ribosomal S6 kinases (RSK)1–4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade . The loss of RSK2 activity in humans leads to Coffin–Lowry syndrome, which is characterized by mental retardation and growth deficits (Hanauer and Young, 2002). Recent work suggests that RSK2 exerts a tonic regulation on G-protein coupled signaling (Sheffler et al., 2006).
Hanauer A, Young ID (2002) Coffin-Lowry syndrome:
clinical and molecular features. J Med Genet
Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hu
feisen SJ, Leahy P, Bruning
JC, Roth BL (2006) p90
ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. Proc Natl Acad Sci
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