|Calculated MW||38 KDa|
|Other Names||Synaptoporin, Synpr|
|Target/Specificity||Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.|
|Format||Prepared from rabbit serum by affinity purification via chromatography on an affinity column made with the C-terminal peptide used as antigen.|
|Antibody Specificity||Specific for ~38k Synaptophysin 2 protein.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Synaptophysin 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Synaptophysin 2, also known as Synaptoporin, is a component of the synaptic vesicle membrane and thought to play an important role in synaptic vesicle trafficking (Dai et al., 2003). It is highly homologous to Synaptophysin 1, yet differs in expression. Whereas Synaptophysin 1 is ubiquit iously expressed, Synaptophysi n 2 is concentrated in the mossy fiber synapses of the hippocampus (Grabs et al., 1994; Singec et al., 2002).
Dai J, Ji C, Gu S, Wu Q, Wang L, Xu J, Zeng L, Ye X, Yin G, Xie Y, Mao Y (2003) Cloning and
sequence analysis of the human cDNA encoding t
he synaptoporin, a highly conserved synaptic
vesicle protein. Molecular Biology Reports 30:185-191.
Singec I, Knoth R, Ditter M, Hagemeyer CE, Rosenbrock H, Frotscher M, Volk B (2002)
Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse
hippocampal neurons. J Comp Neurol 452(2):139-153.
Grabs D, Bergmann M, Schuster T, Fox PA, Brich M, Gratz M (1994) Differential expression of
synaptophysin and synaptoporin during pre- and pos
tnatal development of the rat hippocampal
network. Eur J Neurosci. 6(11): 1765-71..
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