|Calculated MW||82 KDa|
|Other Names||Sodium- and chloride-dependent GABA transporter 2, GAT-2, Solute carrier family 6 member 13, Slc6a13, Gabt2, Gat-2|
|Target/Specificity||Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.|
|Format||Prepared from rabbit serum by affinity purification.|
|Antibody Specificity||Specific for the ~82k GAT-2 protein.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GABA Transporter (GAT) 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-2 is found in a wide range of neuronal and non-neuronal cells including dendrites and axon terminals as well as epithelial cells and cells forming the pia and arachnoid complex (Conti et al., 1999).
Conti F, Zucharello LV, Barbaresi P, Minelli A, Brecha NC, Melone M, (1999) Neuronal, glial, and epithelial localization of gamma-aminobutyric acid transporter 2, a high affinity gamma-aminobutyric acid plasma membrane transporter, in the cerebral cortex and neighboring structures. J. Comp Neurol. 409(3): 482-494.
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