|Calculated MW||67 KDa|
|Other Names||Sodium- and chloride-dependent GABA transporter 3, GAT-3, Solute carrier family 6 member 11, Slc6a11, Gabt3, Gat-3, Gat-b|
|Target/Specificity||Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.|
|Format||Prepared from rabbit serum by affinity purification via chromatography with a column made with the peptide used as antigen.|
|Antibody Specificity||Specific for the ~67k GAT-3 protein. Immunolabeling is blocked by thepeptide used as antigen.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GABA Transporter (GAT) 3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-3 has been found to be localized to astrocytes within the cerebral cortex indicating that this transporter mediates GABA uptake into glial cells (Minelli et al., 1996).
Minelli A, DeBiasi S, Brecha NC, Zuccarello LV, Conti F (1996) GAT-3, a high-affinity GABA plasma
membrane transporter, is localized to astrocytic processes, and is not confined to the vicinity of
GABAergic synapses in the cerebral cortex. J. Neurosci. 16(19):6255-64.
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