|Reactivity||Human, Mouse, Rabbit|
|Calculated MW||46 KDa|
|Other Names||2', 3'-cyclic-nucleotide 3'-phosphodiesterase, CNP, CNPase, Cnp, Cnp1|
|Target/Specificity||Endogenous rabbit 2,3 cyclic nucleotide-3-phospho-diesterase.|
|Antibody Specificity||Specific for the ~ 46k CNP protein in Western blots|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNP (2,3-cyclic nucleotide-3-phosphodiesterase) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
2,3-cyclic nucleotide-3-phosphodiesterase (CNP) is a membrane bound, microtubule associated protein that is among the most abundant myelin proteins of the CNS. It is thought that CNP may serve as a regulator of tubulin polymerization and of microtubule distribution (Bifulco et al., 2002). It was recently found that CNP may also function as a possible linker protein anchoring microtubules to the plasma membrane via a 13 residue C-terminal CNP fragment (Bifulco et al., 2002, Esposito et al., 2008).
Bifulco et al. 2,3-Cyclic nucleotide 3-phosphodiesterase: a membrane bound, microtubule-associated protein and membrane anchor tubulin. PNAS 99:1807-12, 2002
Esposito C, Scrima M, Carotenuto A, Tedeschi A, Rovero P, D’Ebifulco M, D’Errico G, Malfitano AM, D’Ursi AM (2008) Structures and micelle locations of the nonlipidated and lipidated C-terminal anchor of 2,3-Cyclic nucleotide 3-phosphodiesterase. Biochemistry 47(1): 308-319.
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