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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Phospho Antibodies   >   Glial Fibrillary Acidic Protein (GFAP) Antibody   

Glial Fibrillary Acidic Protein (GFAP) Antibody

Chicken polyclonal antibody

  • WB - Glial Fibrillary Acidic Protein (GFAP) Antibody AN1144
    Western blot of rat cortex lysate showing specific immunolabeling of the ~ 50k GFAP protein.
  • IF - Glial Fibrillary Acidic Protein (GFAP) Antibody AN1144
    Mixed cultures of neurons and glia stained with chicken anti-GFAP (red), and DNA (blue).Astrocytes stain strongly and specifically in a clearly filamentous fashion with this antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q28115
Reactivity Rat
Predicted Human, Mouse
Host chicken
Clonality polyclonal
Calculated MW 50 KDa
Additional Information
Gene ID 281189
Gene Name GFAP
Other Names Glial fibrillary acidic protein, GFAP, GFAP
Target/Specificity Recombinant and purified bovine GFAP.
Dilution WB~~ 1:10000
IF~~ 1:1000
Format Total IgY fraction
Antibody Specificity Specific for the ~50kDa GFAP protein. A lower band at ~45kDa is a proteolytic fragment derived from the GFAP molecule.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGlial Fibrillary Acidic Protein (GFAP) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Research Areas
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Glial Fibrillary Acidic Protein (GFAP) was discovered by Amico Bignami and co-workers as a major fibrous protein of multiple sclerosis plaques (1). It was subsequently found to be a member of the 10nm or intermediate filament (IF) family, specifically the IF family Class III, which also includes peripherin, desmin and vimentin. GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the CNS, in satellite cells, peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition, neural stem cells frequently strongly express GFAP. Point mutations in the protein coding region of the GFAP gene lead to Alexander disease which is characterized by the presence of abnormal astrocytes containing GFAP protein aggregates known as Rosenthal fibers (2).


1. Bignami A, Eng LF, Dahl D, Uyeda CT. Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence. Brain Res. 43:429-35 (1972).
2. Brenner M, Johnson AB, Boespflug-Tanguy O, Rodriguez D, Goldman JE and Messing A. Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease. Nat Genet 27:117-20 (2001)

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$ 285.00
Cat# AN1144
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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