|Application ||WB, FC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||22 KDa|
|Other Names||Phosphatidylethanolamine-binding protein 1, PEBP-1, 23 kDa morphine-binding protein, HCNPpp, P23K, Hippocampal cholinergic neurostimulating peptide, HCNP, Pebp1, Pbp, Pebp|
|Target/Specificity||Purified native rat PEBP.|
|Antibody Specificity||Specific for the ~ 22k PEBP protein in Western blots|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PEBP (Phosphatidylethanolamine Binding Protein) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Phosphatidylethanolamine binding protein (PEBP), also known as Raf kinase inhibitory protein (RKIP) is a highly conserved multifunctional protein that modulates the Raf/MAPK signaling cascade and has been implicated as a suppressor of metastatic cancer (Trakul N et al., 2005). PEBP has been shown to not only inhibit cell proliferation but also to induce differentiation of human keratinocytes (Yamazaki et al., 2004). Dysregulation of calpain activity results in cellular degeneration in conditions such as Alzheimer’s disease and recently PEBP has been identified as a potential in vivo calpain substrate (Chen at al., 2006).
Trakul N, Menard RE, Schade GR, Qian Z, Rosner MR (2005) Raf kinase inhibitory protein regulates Raf-1 but not BRaf
kinase activation. J. Biol. Chem. 280(26): 24931-40.
Yamazaki T, Nakano H, Hayakari M, Tanaka M, Mayama J, Tsuchida S (2004) Differentiation induction of human
keratinocytes by phosphatidylethanolamine binding protein. J. Biol. Chem. 279(31):32191-95.
Chen Q, Wang S, Thompson SN, Hall ED, Guttmann RP (2006) Identification and characterization of PEBP as a
calpain substrate. J Neurochem. 99(4): 1133-41.
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