|Application ||WB, IF|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||57 KDa|
|Other Names||Peripherin, Prph, Prph1|
|Target/Specificity||Recombinant rat peripherin expressed in and purified from E. coli.|
|Format||Unpurified, concentrated culture supernatant.|
|Antibody Specificity||Specific for the ~57kDa peripherin protein. This antibody performs well on aldehyde fixed tissues.|
|Precautions||Peripherin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Peripherin is a ~57kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury (1). Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors (2). Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes (3). Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration.
1. Terao E, Janssens S, van den Bosch de Aquilar P, Portier M, Klosen P (2000) In vivo
expression of the intermediate filament peripherin in rat motorneurons: modulation by
inhibitory and stimulatory signals. Neuroscience 101(3):679-88.
Roberson J, Doroudchi MM, Nguyen MD, Durham, HD, Shaw G, Julien JP, Mushynski
WE. (2003) A neurotoxic peripherin splice variant in a mouse model of ALS. J. Cell Biol. 160(6):939-49.
Boitard C, Villa MC, Becourt C, Gia HP, Huc C, Sempe P, Portier MM, Bach JF (1992)
Peripherin: an islet antigen that is cross-reactive with nonobese diabetic mouse class II gene products. Proc Natl Acad Sci USA 89(1):172-6.
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