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Peripherin Antibody

Chicken polyclonal antibody

  • WB - Peripherin Antibody AN1155
    Western blot of rat cerebellar lysate showing specific immunolabeling of the ~ 57k peripherin protein.
  • IF - Peripherin Antibody AN1155
    Immunostaining of cultured rat neurons and glia showing peripherin in green and alpha-internexin in red. Cells expressing both peripherin and alpha-internexin appear yellow.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21807
Reactivity Rat
Host Chicken
Clonality polyclonal
Calculated MW 57 KDa
Additional Information
Gene ID 3414
Gene Name PRPH
Other Names Peripherin, Prph, Prph1
Target/Specificity Recombinant rat peripherin expressed in and purified from E. coli.
Dilution WB~~ 1:1000
IF~~ 1:500
Format Total IgY fraction
Antibody Specificity Specific for the ~57kDa peripherin protein.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPeripherin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Peripherin is a ~57kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury (1). Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors (2). Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes (3). Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration.


1. Terao E, Janssens S, van den Bosch de Aquilar P, Portier M, Klosen P (2000) In vivo
expression of the intermediate filament peripherin in rat motorneurons: modulation by
inhibitory and stimulatory signals. Neuroscience 101(3):679-88.
Roberson J, Doroudchi MM, Nguyen MD, Durham, HD, Shaw G, Julien JP, Mushynski
WE. (2003) A neurotoxic peripherin splice variant in a mouse model of ALS. J. Cell Biol. 160(6):939-49.
Boitard C, Villa MC, Becourt C, Gia HP, Huc C, Sempe P, Portier MM, Bach JF (1992)
Peripherin: an islet antigen that is cross-reactive with nonobese diabetic mouse class II gene products. Proc Natl Acad Sci USA 89(1):172-6.

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$ 285.00
Cat# AN1155
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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