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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Phospho Antibodies   >   Phospho Ser416 Tau Antibody   

Phospho Ser416 Tau Antibody

Affinity purified rabbit polyclonal antibody

  • WB - Phospho Ser416 Tau Antibody AN1156
    Western blot of rat brain homogenate showing specific immunolabeling of the~59, 65, 68k Tau isoforms phosphorylated at Ser416(control). Immunolabeling isblocked by preadsorption with the phospho-peptide used as antigen (Peptide)but not by the corresponding dephospho-peptide (not shown).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P19332
Reactivity Rat
Predicted Bovine, Human, Mouse, Monkey
Host Rabbit
Clonality polyclonal
Calculated MW 59/65/68 KDa
Additional Information
Gene ID 69329
Gene Name MAPT
Other Names Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, Mapt, Mtapt, Tau
Target/Specificity Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser416 conjugated to KLH.
Dilution WB~~ 1:1000
Format Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.
Antibody Specificity Specific for ~59, 65, 68k tau protein phosphorylated at Ser416.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho Ser416 Tau Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Research Areas
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Tau is a key microtubule-associated protein that plays an important role in the formation of microtubules in axons (Binder et al. 1985). Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing (Goedert 1990). Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer’s disease (AD), Pick’s disease and progressive supranuclear palsy. It has been well documented that hyperphosphorylated tau is a major component of paired helical filaments in AD brain (Lee 1995). Serine 416 has been demonstrated to be a major phosphorylation site in vitro by CaM kinase II (Steiner at al. 1990).


Binder LI, Frankfurter A, Rebhun LI (1985) The distribution of tau in the mammalian central
nervous system. J Cell Bio Oct; 101(4):1371-8.
Lee V.M.Y. (1995) Disruption of the cytoskeleton in Alzheimer’s disease. Curr. Opin. Neurobiol.
5, 663-668.
Goedert M. and Jakes R. (1990) Expression of separate isoforms of human tau protein:
correlation with the tau pattern in brain and effects on tubulin polymerization. EMBO J 9, 4225-
Steiner B., Mandelkow E.M., Biernat J. et al. (1990) Phosphorylation of microtubuleassociated
protein tau: identification of the site for Ca2+-calmodulin dependent kinase and
relationship with tau phosphorylation in Alzheimer tangles. EMBO J. 9, 3539-3544.

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$ 335.00
Cat# AN1156
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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