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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Phospho Antibodies   >   Ubiquitin C Terminal Hydrolase 1 (UCHL1) Antibody   

Ubiquitin C Terminal Hydrolase 1 (UCHL1) Antibody

Mouse monoclonal antibody

  • WB - Ubiquitin C Terminal Hydrolase 1 (UCHL1) Antibody AN1157
    Western blot of rat hippocampal homogenate showing specific immunolabeling ofthe ~ 24k UCHL1 protein.
  • IF - Ubiquitin C Terminal Hydrolase 1 (UCHL1) Antibody AN1157
    Rat spinal cord stained with anti-UCHL1(red) and anti-neurofilament NF-H antibody (green). The large cells are α-motorneurons and UCHL1 fills the cytoplasm of their perikaryaand dendrites.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P09936
Reactivity Bovine, Human, Rat
Host Mouse
Clonality monoclonal
Isotype IgG1
Clone Names BH7
Calculated MW 24 KDa
Additional Information
Gene ID 7345
Gene Name UCHL1
Other Names Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, 6---, Neuron cytoplasmic protein 95, PGP 95, PGP95, Ubiquitin thioesterase L1, UCHL1
Target/Specificity Recombinant full length human UCHL1 purified from E. coli.
Dilution WB~~ 1:5000
IF~~ 1:500
Format Unpurified, concentrated culture supernatant
Antibody Specificity Specific for the ~24kDa UCHL1 protein.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUbiquitin C Terminal Hydrolase 1 (UCHL1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Research Areas
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Ubiquitin C-terminal hydrolase 1 (UCHL1) is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5 (1). It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein (2). The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice (3). Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease (4). Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker. Anti-UCHL1


1. Doran JF, Jackson P, Kynoch PA, Thompson RJ. Isolation of PGP 9.5, a new human neurone-specific protein detected by high-resolution two-dimensional electrophoresis. J Neurochem. 40:1542-7 (1983).
2. Wilkinson KD, Lee KM, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. Science. 1989 246:670-3 (1989).
3. Kurihara LJ, Kikuchi T, Wada K, Tilghman SM. Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia. Hum Mol Genet. 10:1963-70 (2001).
4. Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT Jr. The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell 111:209-18 (2002).

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$ 285.00
Cat# AN1157
(40 western blots)
Availability: 7-10 days
Bulk Size
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