|Reactivity||Human, Mouse, Rat|
|Calculated MW||64 KDa|
|Other Names||Nuclear receptor subfamily 2 group C member 2, Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, Testicular receptor 4, Nr2c2, Mtr2r1, Tak1, Tr4|
|Target/Specificity||Fusion protein from the N-terminal region of mouse TR4.|
|Antibody Specificity||Specific for the ~64 kDa TR4 protein by Western blot in cerebellum and nuclear extracts from MEL cell lines.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Testicular Receptor 4 (TR4) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Testicular receptor 4 (TR4) is a member of the orphan nuclear receptor superfamily. Data suggests that TR4 may function as a regulator that modulates many signaling pathways. It has been suggested that TR4 is required for normal cerebellar development as TR4 knockout mice exhibit behavioral deficits in motor coordination (Chen, YT et al.,2008) and plays important roles in growth, embryonic and early postnatal survival (Collins, LL, et al., 2004).
Chen YT, Collins LL, Chang SS, Chang C (2008) The roles of testicular orphan nuclear receptor
4 (TR4) in cerebellar development. Cerebellum 7(1):9-17.
Collins LL, Lee YF, Heinlein CA, Liu NC, Chen YT, Shyr CR, Meshul CK, Uno H, Platt KA,
Chang C (2004) Growth retardation and abnormal maternal behavior in mice lacking testicular
orphan nuclear receptor 4. PNAS 101(42):15058-63
Tanabe O, Shen Y, Liu Q, Campbell AD, Kuroha T, Yamamoto M, Engel JD. “The TR2 and TR4
orphan nuclear receptors repress Gata1 transcription.” Genes Dev. 2007, 21:2832-2844.
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