|Reactivity||Chicken, Human, Mouse|
|Calculated MW||93 KDa|
|Other Names||Periostin, PN, Osteoblast-specific factor 2, OSF-2, Postn, Osf2|
|Target/Specificity||Synthetic peptide corresponding to amino acid residues from the fasciclin domain 1 of mouse periostin.|
|Antibody Specificity||Specific for three periostin bands around ~93 kDa in mouse lungextract. The immunogenic peptide is present in all known splice variants of periostin andtherefore this antibody recognizes all known molecular forms of periostin. The antibody alsoworks well for immunohistochemistry on paraformaldehyde-fixed sections with a simple antigenretrievalprotocol (incubate slides for 20 minutes at 90º C in 10 mM sodium citrate (pH 6.0)/ 0.1% Tween-20).|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Periostin, pan Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Periostin is a matricellular protein, i.e. an extracellular matrix protein that interacts both with other ECM proteins and with cell-surface receptors. Like many other matricellular proteins, the function of periostin is important both in embryonic development and in the remodeling of adult tissues in response to pathological insults. Periostin was originally isolated as an osteoblast-specific marker that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading (Kruzynska-Frejtag A. et al., 2004). Periostin has recently been shown to promote collagen fibrogenesis, inhibit differentiation of progenitor cells into cardiomyocytes and to be essential in maintaining the biomechanical properties of the adult myocardium (Norris et al., 2008)
Kruzynska-Frejtag A, Wang J, Rogers R, Krug E, Hoffman S, Markwald RR, Conway SJ. (2004)
Periostin is expressed within the developing teeth at the sites of epithelial-mesenchymal
interaction. Develop Dynamics, 229:857-868.
Norris RA, Borq TK, Butcher JT, Baudino TA, Banerjee I, Markwald RR (2008) Neonatal and
adult cardiovascular pathophysiological remodeling and repair: developmental role of periostin.
Ann NY Acad Sci. 1123:30-40.
Norris RA, Damon B, Mironov V, Kasyanov V, Ramamurthi A, Moreno-Rodriguez R, Trusk T,
Potts JD, Goodwin RL, Davis J, Hoffman S, Wen X, Sugi Y, Kern CB, Mjaatvedt CH, Turner DK,
Oka T, Conway SJ, Molkentin JD, Forgacs G, Markwald RR. (2007) Periostin regulates collagen
fibrillogenesis and the biomechanical properties of connective tissues. J Cell Biochem.
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