Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
Periostin, pan Antibody
Rabbit polyclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q62009 |
| Reactivity | Chicken, Human, Mouse |
| Host | Rabbit |
| Clonality | polyclonal |
| Calculated MW | 93 KDa |
| Gene ID | 50706 |
|---|---|
| Gene Name | POSTN |
| Other Names | Periostin, PN, Osteoblast-specific factor 2, OSF-2, Postn, Osf2 |
| Target/Specificity | Synthetic peptide corresponding to amino acid residues from the fasciclin domain 1 of mouse periostin. |
| Dilution | WB~~ 1:1000 |
| Format | Affinity purified |
| Antibody Specificity | Specific for three periostin bands around ~93 kDa in mouse lungextract. The immunogenic peptide is present in all known splice variants of periostin andtherefore this antibody recognizes all known molecular forms of periostin. The antibody alsoworks well for immunohistochemistry on paraformaldehyde-fixed sections with a simple antigenretrievalprotocol (incubate slides for 20 minutes at 90º C in 10 mM sodium citrate (pH 6.0)/ 0.1% Tween-20). |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Periostin, pan Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Periostin is a matricellular protein, i.e. an extracellular matrix protein that interacts both with other ECM proteins and with cell-surface receptors. Like many other matricellular proteins, the function of periostin is important both in embryonic development and in the remodeling of adult tissues in response to pathological insults. Periostin was originally isolated as an osteoblast-specific marker that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading (Kruzynska-Frejtag A. et al., 2004). Periostin has recently been shown to promote collagen fibrogenesis, inhibit differentiation of progenitor cells into cardiomyocytes and to be essential in maintaining the biomechanical properties of the adult myocardium (Norris et al., 2008)
References
Kruzynska-Frejtag A, Wang J, Rogers R, Krug E, Hoffman S, Markwald RR, Conway SJ. (2004)
Periostin is expressed within the developing teeth at the sites of epithelial-mesenchymal
interaction. Develop Dynamics, 229:857-868.
Norris RA, Borq TK, Butcher JT, Baudino TA, Banerjee I, Markwald RR (2008) Neonatal and
adult cardiovascular pathophysiological remodeling and repair: developmental role of periostin.
Ann NY Acad Sci. 1123:30-40.
Norris RA, Damon B, Mironov V, Kasyanov V, Ramamurthi A, Moreno-Rodriguez R, Trusk T,
Potts JD, Goodwin RL, Davis J, Hoffman S, Wen X, Sugi Y, Kern CB, Mjaatvedt CH, Turner DK,
Oka T, Conway SJ, Molkentin JD, Forgacs G, Markwald RR. (2007) Periostin regulates collagen
fibrillogenesis and the biomechanical properties of connective tissues. J Cell Biochem.
101(3):695-711.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
