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Collagen I α1 Propeptide Sequence Antibody

Rabbit polyclonal antibody

  • WB - Collagen I α1 Propeptide Sequence Antibody AN1185
    Western blot of rat lung lysate showing specific immunolabeling of the ~180 k collagen 1.
  • IHC - Collagen I α1 Propeptide Sequence Antibody AN1185
    IHC of fibrotic mouse lung tissue showing specific staining of collagen I molecules (red) that are still associated with the cells in which they were synthesized.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02452
Reactivity Human, Mouse
Host Rabbit
Clonality polyclonal
Calculated MW 180 KDa
Additional Information
Gene ID 1277
Gene Name COL1A1
Other Names Collagen alpha-1(I) chain, Alpha-1 type I collagen, COL1A1
Target/Specificity Synthetic peptide corresponding to amino acid residues specific to the collagen 1, alpha 1 propeptide conjugated to KLH.
Dilution WB~~ 1:1000
IHC~~ 1:100
Format Affinity purified
Antibody Specificity Specific for the propeptide portion of the ~180 kDa collagen I α1polypeptide in human lung fibroblast extract. The antibody also works well forimmunohistochemistry on paraformaldehyde-fixed sections with a simple antigen-retrievalprotocol (incubate slides for 20 minutes at 90º C in 10 mM sodium citrate (pH 6.0)/ 0.1 %Tween-20). Note that in paraffin sections of formaldehyde-fixed fibrotic mouse lung tissue, theantibody recognizes collagen I molecules that are still associated with the cells in which theywere synthesized.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCollagen I α1 Propeptide Sequence Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Research Areas
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Collagen is an extracellular matrix protein that serves as a scaffold defining the shape and mechanical properties of many tissues and organs including skin, tendon, artery walls, fibrocartilage, bone and teeth. Type 1 collagen is the must abundant protein in mammals. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the fist 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procollagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005).


Byers PH (1989) Inherited disorders of collagen gene structure and expression. Am J Med
Genet. 34(1):72-80.
Cabral WA, Makareeva E, Colige A, Letocha AD, Ty JM, Yeowell HN, Pals G, Leikin S, Marini
JC. (2005) Mutations near amino end of alpha1(I) collagen cause combined osteogenesis
imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing. J Biol Chem.
2005 May 13;280(19):19259-69.

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$ 335.00
Cat# AN1185
(40 western blots)
Availability: 7-10 days
Bulk Size
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