|Reactivity||Human, Mouse, Rat|
|Calculated MW||58 KDa|
|Other Names||Alpha-ketoglutarate-dependent dioxygenase FTO, 11411-, Fat mass and obesity-associated protein, FTO, KIAA1752|
|Target/Specificity||Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH.|
|Format||Protein G purified culture supernatant.|
|Antibody Specificity||Specific for the ~58 kDa Fto protein in Western blots of rat testes lysate.The antibody has also been used for immunocytochemistry with neuronal progenitor cells.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Fto (Fat mass and obesity-associated protein) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The FTO gene is the most robust gene for common obesity characterized to date. FTO gene expression has been found to be significantly upregulated in the hypothalamus of rats after food deprivation and strongly negatively correlated with the expression of orexin peptide which is involved in the stimulation of food intake (Fredricksson R et al., 2008). Deletion analysis of FTO gene in mice showed that Fto is functionally involved in the control of both energy intake and energy expenditure (Fischer J et al., 2009)
Fredriksson R, Hägglund M, Olszewski PK, Stephansson O, Jacobsson JA, Olszewska AM,
Levine AS, Lindblom J, Schiöth HB (2008). The obesity gene, FTO, is of ancient origin,
upregulated during food deprivation and expressed in neurons of feeding-related nuclei of the
brain. Endocrinology 149: 2062.
Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Brüning JC, Rüther U. (2009).
Inactivation of the Fto gene protects from obesity. Nature 458: 894.
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