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alpha Synuclein Antibody

Mouse monoclonal antibody

  • WB - alpha Synuclein Antibody AN1190
    Western blot of rat brain lysate showing specific immunolabeling of the ~ 15k alphasynuclein protein.
  • IF - alpha Synuclein Antibody AN1190
    Mixed neuron-glial cultures stained with alpha-synuclein (red) andchicken MAP2 (green). The alpha-synuclein antibody stains vesicular structures, the perikarya and processes of the neurons in this image.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P37840
Reactivity Human, Mouse, Rat
Host Mouse
Clonality monoclonal
Isotype IgG1
Clone Names 3H9
Calculated MW 15 KDa
Additional Information
Gene ID 6622
Gene Name SNCA
Other Names Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, SNCA, NACP, PARK1
Target/Specificity Full length human alpha synuclein expressed in E. Coli.
Dilution WB~~ 1:1000
IF~~ 1:500
Format Mouse ascites fluid.
Antibody Specificity Specific for the ~15kDa alpha Synuclein protein.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautionsalpha Synuclein Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Research Areas
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Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson’s disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Early onset Parkinson's disease may be caused by a duplication or triplication of one of the alpha synuclein genes (Chartier-Harlin MC et al., 2004 and Singleton, AB et al., 2005). Alpha-synuclein is also found in the Lewy bodies of patients with diffuse Lewy body disease and inclusions in glial cells in the brains of patients with multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS).


Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C (2000) Constitutive phosphorylation of the Parkinson’s disease associated alpha-synuclein. J Biol Chem Jan 7;275(1): 390-7.
Chartier-Harlin, MC. et al. Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 364: 1167-1169 (2004).
Singleton, AB et al. Alpha-synuclein locus triplication causes Parkinson's disease. Science 302: 841 (2003).

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$ 285.00
Cat# AN1190
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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