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Phospho Ser862 mGluR7 Antibody

Affinity purified rabbit polyclonal antibody

  • FC - Phospho Ser862 mGluR7 Antibody AN1202
    Flow cytometric analysis of SH-SY5Y cells using Phospho Ser862 mGluR7 Antibody(green, Cat#AN1202) compared to an isotype control of rabbit IgG(blue). AN1202 was diluted at 1:500 dilution. An Alexa Fluor® 488 goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody.
  • WB - Phospho Ser862 mGluR7 Antibody AN1202
    Western blot of mouse brain lysate showing the specific immunolabelingof the ~102k mGluR7 protein phosphorylated at Ser862. Immunolabelingis blocked by the phospho-peptide used as antigen (peptide) but not by thecorresponding dephospho-peptide (not shown).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P35400
Reactivity Mouse, Rat
Predicted Bovine, Human, Monkey, Zebrafish
Host Rabbit
Clonality polyclonal
Calculated MW 102 KDa
Additional Information
Gene ID 81672
Gene Name GRM7
Other Names Metabotropic glutamate receptor 7, mGluR7, Grm7, Gprc1g, Mglur7
Target/Specificity Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser862 conjugated to KLH.
Dilution FC~~1:500
WB~~ 1:1000
Format Prepared from rabbit serum by affinity purification via sequential chromatography on phospho and dephospho-peptide columns.
Antibody Specificity Specific for the ~102k mGluR7 protein phosphorylated at Ser862. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide used as antigen but not by the corresponding dephosphopeptide.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho Ser862 mGluR7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Research Areas
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Metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). The mGluRs are divided into three groups based on sequence identity and pharmacological properties: group I (mGluR1 and mGluR5) are localized in the perisynaptic region of the postsynaptic membrane, whereas group II (mGlur2 and mGluR3) and group III (mGluR4,6,7 and 8) are localized predominantly at presynaptic terminals. PKC phosphorylation of serine 862 on mGluR7 has been shown to be critical for stabilizing receptor surface expression and promoting binding to the synaptic PDZ-domain-containing protein PICK1 (Suh et al., 2008).


Bhattacharya M, Babwah AV, Godin C, Anborgh PH, Dale LB, Poulter MO, Ferguson SSG (2004) Ral and phospholipase D2-dependent pathway for constitutive metabotropic glutamate receptor endocytosis. J Neurosci 24:8752-8761.
Francesconi W, Cammalleri M, Sanna PP (2004) The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region. Brain Res 1022:12-18.
Wilson RI, Nicoll RA (2001) Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. Nature (London) 410:588-592.
Suh YH, Pelkey KA, Lavezzari G, Roche PA, Huganir RL, McBain CJ, Roche KW. (2008) Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7. Neuron. 58(5):736-48

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$ 335.00
Cat# AN1202
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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