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Doublecortin (DCX) Antibody

Mouse monoclonal antibody

     
  • WB - Doublecortin (DCX) Antibody AN1217
    Western blot of postnatal day 3 rat brain lysate showing specific immunolabeling of the ~35 & 45k doublecortin protein.
    detail
  • IF - Doublecortin (DCX) Antibody AN1217
    Immunofluorescence of cultured rat neurons showing strong cytoplasmicstaining of doublecortin (green) in developing neurons and GFAP in red.
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IF, WB
Primary Accession O43602
Reactivity Bovine, Human, Mouse, Rat
Host Mouse
Clonality monoclonal
Isotype IgG2A
Clone Names 3 e1
Calculated MW 35, 45 KDa
Additional Information
Gene ID 1641
Gene Name DCX
Other Names Neuronal migration protein doublecortin, Doublin, Lissencephalin-X, Lis-X, DCX, DBCN, LISX
Target/Specificity Full length recombinant human protein expressed in and purified from E. coli.
Dilution WB~~ 1:5000
IF~~ 1:1000
Format Affinity purified from tissue culture supernatant.
Antibody Specificity Specific for the ~35 & 45 k doublecortin protein.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDoublecortin (DCX) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ShippingBlue Ice
Research Areas
Citations (0)
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Background

Doublecortin, or DCX, is a microtubule associated protein that is expressed almost exclusively in very early neuronal development (Brown et al., 2003), making it an excellent marker for developing neuronal cells. Defects in the DCX gene lead to X-linked lissencephaly which is characterized by a lack of normal folds on the surface of the brain resulting in a smooth cerebral cortex caused by abnormal migration of neurons during development (des Portes et al., 1998; Gleeson et al., 1998).

References

Brown JP, Couillard-Després S, Cooper-Kuhn CM, Winkler J, Aigner L, Kuhn HG (2003) Transient expression of doublecortin during adult neurogenesis. J Comp Neurol. Dec 1;467(1):1-10.
des Portes V, Pinard JM, Billuart P, Vinet MC, Koulakoff A, Carrié A, Gelot A, Dupuis E, Motte J, Berwald-Netter Y, Catala M, Kahn A, Beldjord C and Chelly J. (1998) A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome. Cell 92:51-61.
Gleeson JG, Allen KM, Fox JW, Lamperti ED, Berkovic S, Scheffer I, Cooper EC, Dobyns WB, Minnerath SR, Ross ME and Walsh CA. (1998) Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein. Cell 92:63-72.

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$ 365.00
Cat# AN1217
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Availability: 7-10 days
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