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Synapsin I Antibody

Affinity purified rabbit polyclonal antibody

  • WB - Synapsin I  Antibody AN1233
    Western blot of 10 ug of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~78k synapsin I doublet protein.
  • IF - Synapsin I  Antibody AN1233
    Immunostaining of cultured rat caudate neurons showing punctate distribution of synapsin in green and MAP in red. Cells and photo courtesy of QBMCellScience.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P17599
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 78 KDa
Additional Information
Gene ID 281510
Gene Name SYN1
Other Names Synapsin-1, Synapsin I, SYN1
Target/Specificity Native protein purified from bovine brain.
Dilution WB~~ 1:1000
IF~~ 1:1000
Format Prepared from rabbit serum by affinity purification using a column to which the native protein was coupled.
Antibody Specificity Specific for the ~78k synapsin I doublet in Western blots of rat brainextracts. Immunolabeling blocked by preadsorption of antibody with the protein used togenerate the antibody.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSynapsin I Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Research Areas
Citations (0)

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Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation (Moore and Bernstein, 1989; Stone et al., 1994). Thus, synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002).


Feng J, Chi P, Blanpied TA, Xu YM, Magarinos AM, Fe
rreira A, Takahashi RH, Kao HT, McEwen BS, Ryan TA,
Augustine GJ, Greengard P (2002) Regulation of neurotransmitter release by synapsin III. J Neurosci 22:4372-
Jovanovic JN, Sihra TS, Nairn AC, Hemmings HC, Jr., Gr
eengard P, Czernik AJ (2001) Opposing changes in
phosphorylation of specific sites in synapsin I during Ca
-dependent glutamate release in isolated nerve
terminals. J Neurosci 21:7944-7953.
Kao HT, Song HJ, Porton B, Ming GL, Hoh J, Abraham M,
Czernik AJ, Pieribone VA, Poo MM, Greengard P (2002) A
protein kinase A-dependent molecular switch in synapsin
s regulates neurite outgrowth. Nature Neurosci 5:431-
Moore RY, Bernstein M (1989) Synaptogenesis in the rat suprachiasmatic nucleus demonstrated by electron
microscopy and synapsin I immunoreactivity. J Neurosci 9:2151-2162.
Nayak AS, Moore CI, Browning MD (1996) CaM kinase II
phosphorylation of the presyn
aptic protein synapsin is
persistently increased during expression of long-term po
tentiation. Proc Natl Acad Sci (USA) 93:15451-15456.
Stone LM, Browning MD, Finger TE (1994) Differential dist
ribution of the synapsins in the rat olfactory bulb. J
Neurosci 14:301-309.
Kurtis D. Davies, Susan M. Goebel-Goody, St
even J. Coultrap, and Michael D. Browning (2008)
Long Term Synaptic
Depression That Is Associated with GluR1 Dephosphorylation but Not
isoxazolepropionic Acid (AMPA) Receptor Internalization
J. Biol. Chem.,
283: 33138 - 33146.
Note: Dr. Michael Browning, co-author of the
cited papers is the President and founder

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$ 335.00
Cat# AN1233
(40 western blots)
Availability: 7-10 days
Bulk Size
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