|Application ||WB, IF|
|Reactivity||Bovine, Human, Mouse, Rat|
|Calculated MW||49 KDa|
|Other Names||Splicing factor 3B subunit 4, Pre-mRNA-splicing factor SF3b 49 kDa subunit, SF3b50, Spliceosome-associated protein 49, SAP 49, SF3B4, SAP49|
|Target/Specificity||Recombinant full length human SAP49 expressed in and purified from E. Coli.|
|Format||Affinity purified from tissue culture supernatant.|
|Antibody Specificity||Specific for the ~49k SAP49 protein|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SAP49 (SF3B4) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The spliceosome associated protein of 49 kDa (SAP49), also known as SF3B4, is a widely expressed nuclear splicing factor that has been shown to have RNA binding activity as well as direct interaction with SAP145 (Champion-Arnaud and Reed 1994). The SAP145-SAP49 complex has recently been implicated in cell cycle progression as Vpr (viral protein 1 of HIV-1) has been shown to bind SAP145 thus interfering with the proper formation and functioning of the SAP145-SAP49 complex (Terada and Yasuda 2006).
. (1994) The prespliceosome compon
ents SAP 49 and SAP 145 interact in a
complex implicated in tethering U2 snRNP to the branch site.
. (2006) Human immunodeficiency virus type 1 Vpr induces G2 checkpoint activation
by interacting with the splicing factor SAP145.
Mol Cell Biol.
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