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SAP49 (SF3B4) Antibody

Mouse monoclonal antibody

  • WB - SAP49 (SF3B4)  Antibody AN1245
    Western blot of HeLa lysate showing specific immunolabeling of the ~ 49k SAP49 protein.
  • IF - SAP49 (SF3B4)  Antibody AN1245
    Immunofluorescence of HeLa cells showing strong granular nuclear staining of SAP49 in red and vimentin in green.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15427
Reactivity Bovine, Human, Mouse, Rat
Host Mouse
Clonality monoclonal
Isotype IgG2b
Clone Names 3A1
Calculated MW 49 KDa
Additional Information
Gene ID 10262
Gene Name SF3B4
Other Names Splicing factor 3B subunit 4, Pre-mRNA-splicing factor SF3b 49 kDa subunit, SF3b50, Spliceosome-associated protein 49, SAP 49, SF3B4, SAP49
Target/Specificity Recombinant full length human SAP49 expressed in and purified from E. Coli.
Dilution WB~~ 1:2000
IF~~ 1:1000
Format Affinity purified from tissue culture supernatant.
Antibody Specificity Specific for the ~49k SAP49 protein
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSAP49 (SF3B4) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ShippingBlue Ice
Research Areas
Citations (0)

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The spliceosome associated protein of 49 kDa (SAP49), also known as SF3B4, is a widely expressed nuclear splicing factor that has been shown to have RNA binding activity as well as direct interaction with SAP145 (Champion-Arnaud and Reed 1994). The SAP145-SAP49 complex has recently been implicated in cell cycle progression as Vpr (viral protein 1 of HIV-1) has been shown to bind SAP145 thus interfering with the proper formation and functioning of the SAP145-SAP49 complex (Terada and Yasuda 2006).


Champion-Arnaud P
Reed R
. (1994) The prespliceosome compon
ents SAP 49 and SAP 145 interact in a
complex implicated in tethering U2 snRNP to the branch site.
Genes Dev.
Terada Y
Yasuda Y
. (2006) Human immunodeficiency virus type 1 Vpr induces G2 checkpoint activation
by interacting with the splicing factor SAP145.
Mol Cell Biol.

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$ 335.00
Cat# AN1245
Availability: 7-10 days
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