|Application ||WB, IF|
|Reactivity||Bovine, Human, Mouse, Rat|
|Calculated MW||22 KDa|
|Other Names||Visinin-like protein 1, VILIP, VLP-1, Hippocalcin-like protein 3, HLP3, VSNL1, VISL1|
|Target/Specificity||Recombinant human VSNL1 purified from E. coli.|
|Dilution||WB~~ 1:2000 |
|Format||Affinity purified from tissue culture supernatant.|
|Antibody Specificity||Specific for the ~22k protein|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Visinin-Like Protein 1 (VSNL1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Visinin-like protein 1 (VSNL1), also known as VILIP1, is a calcium sensor protein expressed exclusively in neurons. Highest levels of VSNL1 expression are found in cerebellar Purkinje cells. VSNL1 has been implicated in the modulation of cell signaling cascades via regulation of adenyl cyclase activity (Braunewell et al., 1997). Additionally, VSNL1 has been associated with amyloid plaques and neurofibrillar tangles in Alzheimer’s disease (Schnurra et al., 2001).
Braunewell KH, Spilker C, Behnisch T, Gundelfinger ED (1997) The neuronal calcium-sensor protein VILIP
modulates cyclic AMP accumulation in stably transfected C6 glioma cells: amino-terminal myristoylation
determines functional activity.
68 (5): 2129–39.
Schnurra I, Bernstein HG, Riederer P, Braunewell KH (2002) The neuronal calcium sensor protein VILIP-1 is
associated with amyloid plaques and
extracellular tangles in Alzheimer's di
sease and promotes cell death and tau
phosphorylation in vitro: a link between calcium sensors and Alzheimer's disease?
8 (5): 900–9.
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