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Phospho-Ser241 Munc18-1 Antibody

Affinity purified rabbit polyclonal antibody

  • WB - Phospho-Ser241 Munc18-1 Antibody AN1250
    Western blot of mouse hippocampus lysate showing specific immunolabeling of the ~65k Munc18-1protein phosphorylated at Ser241. Phosphospecificity is shown in the second lane whereimmunolabeling is blocked by treatment of the lysate with lambda phosphatase (P-tase).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O08599
Reactivity Mouse
Predicted Bovine, Chicken, Human, Monkey, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 65 KDa
Additional Information
Gene ID 20910
Gene Name STXBP1
Other Names Syntaxin-binding protein 1, Protein unc-18 homolog 1, Unc18-1, Protein unc-18 homolog A, Unc-18A, Stxbp1
Target/Specificity Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser241 conjugated to KLH.
Dilution WB~~ 1:1000
Format Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
Antibody Specificity Specific for the ~65k Munc18-1 protein phosphorylated at Ser241. Immunolabeling is blocked by the treatment of the lysate with lambda phosphatase (30 minutes, 800 units / 1 mg protein).
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-Ser241 Munc18-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Munc-18 (mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part, to it ability to bind syntaxin (Ciufo et al., 2005). Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex (Liu et al., 2004). The function of Munc18-1 is thought to be regulated by phosphorylation.


Ciufo LF, Barclay JW, Burgoyne RD, Morgan A (2005) Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions. Mol Biol Cell 16:470-482.
Liu J, Ernst SA, Gladycheva SE, Lee YY, Lentz SI, Ho CS, Li Q, Stuenkel EL (2004) Fluorescence resonance energy transfer reports properties of syntaxin1a interaction with Munc18-1 in vivo. J Biol Chem 279:55924-55936.

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$ 335.00
Cat# AN1250
(40 western blots)
Availability: 7-10 days
Bulk Size
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