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Apoa5 (ab) Antibody

Purified Mouse Monoclonal Antibody

  • WB - Apoa5 (ab) Antibody AO1006a
    Figure 1: Western blot analysis using Apoa5 mouse mAb against human serum (1) and Apoa5 recombinant protein (2).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6Q788
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1G5G9(c); 2G1H11G9B3
Isotype IgG1
Calculated MW 41213 Da
Description Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four fold increase in serum triglycerides, whereas a knock-in model with human ApoA5 produced 50–70% lower concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor-_ agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Recently, it was demonstrated that ApoA5 is present in human serum detected by polyclonal antibodies against both the NH2 and COOH termini, although at much lower concentration than other apolipoproteins.
Immunogen Purified recombinant fragment of human APOA5 (AA: 20-363) expressed in E. Coli.
Formulation Purified antibody in PBS containing 0.03% sodium azide.
Additional Information
Gene ID 116519
Other Names Apolipoprotein A-V, Apo-AV, ApoA-V, Apolipoprotein A5, Regeneration-associated protein 3, APOA5, RAP3
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsApoa5 (ab) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APOA5
Synonyms RAP3
Function Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.
Cellular Location Secreted.
Tissue Location Liver and plasma.
Research Areas
Citations (0)

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1.Pennacchio, L, Science 2001. 294, 169-173. 2.Prieur, X. J Biol Chem 2003. 278, 25468-25480.

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$ 385.00
Cat# AO1006a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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