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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   IL-10 Antibody   

IL-10 Antibody

Purified Mouse Monoclonal Antibody

  • WB - IL-10 Antibody AO1011a
    Figure 1: Western blot analysis using IL10 mouse mAb against IL10 recombinant protein.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P22301
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3C12C12
Isotype IgG1
Calculated MW 20517 Da
Description Interleukine 10 (IL-10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
Immunogen Purified recombinant fragment of human IL-10 expressed in E. Coli.
Formulation Purified antibody in PBS containing 0.03% sodium azide.
Additional Information
Gene ID 3586
Other Names Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF, IL10
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIL-10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL10
Function Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
Cellular Location Secreted.
Tissue Location Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types
Research Areas
Citations (0)

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1. Vieira P, et al. PNAS, 1991.88:1172-1176.

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$ 300.00
Cat# AO1011a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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