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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   IL-16 Antibody   

IL-16 Antibody

Purified Mouse Monoclonal Antibody

  • WB - IL-16 Antibody AO1012a
    Figure 1: Western blot analysis using IL16 mouse mAb against IL16 recombinant protein.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14005
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5D8
Isotype IgG1
Calculated MW 141752 Da
Description Interleukin-16, also known as lymphocyte chemoattractant factor (LCF), is a chemotactic cytokine that stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils through binding to the CD4 receptor . IL-16 induces human T-lymphocyte expression of interleukin 2 receptor and upregurates major histocompatibility complex Ⅱmolecules on resting human T lymphocyte. It is able to render CD4+ T cells unresponsive to TCR/CD3 stimuli. Moreover, IL-16 inhibits the replication of T cell and monocyte tropic HIV strains in vitro.
Immunogen Purified recombinant fragment of human IL-16 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 3603
Other Names Pro-interleukin-16, Interleukin-16, IL-16, Lymphocyte chemoattractant factor, LCF, IL16
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIL-16 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL16
Function Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 3 is involved in cell cycle progression in T- cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Cellular Location Interleukin-16: Secreted. Isoform 3: Cytoplasm. Nucleus.
Tissue Location Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation
Research Areas
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1. Cruikshank, W.W. et al 1994. Proc. Nat. Acad. Sci. 91: 5109-5113.

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$ 300.00
Cat# AO1012a
(40 western blots)
Availability: 7-10 days
Bulk Size
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