|Application ||WB, E|
|Calculated MW||141752 Da|
|Description||Interleukin-16, also known as lymphocyte chemoattractant factor (LCF), is a chemotactic cytokine that stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils through binding to the CD4 receptor . IL-16 induces human T-lymphocyte expression of interleukin 2 receptor and upregurates major histocompatibility complex Ⅱmolecules on resting human T lymphocyte. It is able to render CD4+ T cells unresponsive to TCR/CD3 stimuli. Moreover, IL-16 inhibits the replication of T cell and monocyte tropic HIV strains in vitro.|
|Immunogen||Purified recombinant fragment of human IL-16 expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Pro-interleukin-16, Interleukin-16, IL-16, Lymphocyte chemoattractant factor, LCF, IL16|
|Dilution||WB~~1/500 - 1/2000|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL-16 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 3 is involved in cell cycle progression in T- cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.|
|Cellular Location||Interleukin-16: Secreted. Isoform 3: Cytoplasm. Nucleus.|
|Tissue Location||Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation|
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1. Cruikshank, W.W. et al 1994. Proc. Nat. Acad. Sci. 91: 5109-5113.
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