|Application ||WB, E|
|Calculated MW||34373 Da|
|Description||Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. KSHV ORF26 open reading frames are juxtaposed and span from nucleotide (nt) 46933 to 47850 of the virus genome. Akula et al (2003) report it acts as a Capsid protein.|
|Immunogen||Purified recombinant fragment of KSHV ORF26 expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Triplex capsid protein VP23 homolog, ORF26|
|Dilution||WB~~1/500 - 1/2000|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KSHV ORF26 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of the major capsid protein, which are linked together by heterotrimers called triplex. These triplex are formed by a single molecule of VP19C and two copies of VP23 which bridge major capsid protein multimers together. Triplexes occupy the local threeflod positions between capsid hexamers and pentamers. Additionally, VP19C is required for efficient transport of VP23 to the nucleus, which is the site of capsid assembly (By similarity).|
|Cellular Location||Virion. Host nucleus|
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