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Mouse TUG Antibody

Purified Mouse Monoclonal Antibody

  • WB - Mouse TUG Antibody AO1041a
    Figure 1: Western blot analysis using TUG mouse mAb against NIH/3T3 cell lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BZE9
Reactivity Mouse
Host Mouse
Clonality Monoclonal
Clone Names 4A11A6G11
Isotype IgG1
Calculated MW 60183 Da
Description The TUG protein contains a UBX domain, for GLUT4. In truncated form, TUG acts in a dominant-negative manner to inhibit insulin-stimulated GLUT4 redistribution in Chinese hamster ovary cells and 3T3-L1 adipocytes. Full-length TUG forms a complex specifically with GLUT4. In 3T3-L1 adipocytes, this complex is present in unstimulated cells and is largely disassembled by insulin. Endogenous TUG is localized with the insulin-mobilizable pool of GLUT4 in unstimulated 3T3-L1 adipocytes, and is not mobilized to the plasma membrane by insulin.
Immunogen Purified recombinant fragment of TUG expressed in E. Coli.
Formulation Purified antibody in PBS containing 0.03% sodium azide.
Additional Information
Gene ID 79058
Other Names Tether containing UBX domain for GLUT4, Alveolar soft part sarcoma chromosomal region candidate gene 1 protein, Alveolar soft part sarcoma locus, Renal papillary cell carcinoma protein 17, UBX domain-containing protein 9, ASPSCR1, ASPL, RCC17, TUG, UBXD9, UBXN9
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse TUG Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ASPL, RCC17, TUG, UBXD9, UBXN9
Function Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT.
Cellular Location Endomembrane system; Peripheral membrane protein. Endoplasmic reticulum- Golgi intermediate compartment membrane; Peripheral membrane protein Cytoplasm. Nucleus
Tissue Location Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas.
Citations (0)

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1. Nature 2003,425:727 - 733.

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$ 300.00
Cat# AO1041a
(40 western blots)
Availability: 7-10 days
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