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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Calcyclin Antibody   

Calcyclin Antibody

Purified Mouse Monoclonal Antibody

  • WB - Calcyclin Antibody AO1044a
    Figure 1: Western blot analysis using calcyclin mouse mAb against truncated calcyclin recombinant protein.
  • IHC - Calcyclin Antibody AO1044a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human brain glioma tissue showing nuclear localization using calcyclin mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HB71
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7D11
Isotype IgG1
Calculated MW 26210 Da
Description Calcyclin encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.
Immunogen Purified recombinant fragment of calcyclin expressed in E. Coli.
Formulation Purified antibody in PBS containing 0.03% sodium azide.
Additional Information
Gene ID 27101
Other Names Calcyclin-binding protein, CacyBP, hCacyBP, S100A6-binding protein, Siah-interacting protein, CACYBP, S100A6BP, SIP
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCalcyclin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms S100A6BP, SIP
Function May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
Cellular Location Nucleus. Cytoplasm. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated
Research Areas
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1. Bean J Mol Biol. 2005 Jun 3;349(2):349-66. 2. HWang J Biol Chem. 2004 May 14;279(20):21239-47.

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$ 300.00
Cat# AO1044a
(40 western blots)
Availability: 7-10 days
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