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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Akt3 Antibody   

Akt3 Antibody

Purified Mouse Monoclonal Antibody

  • WB - Akt3 Antibody AO1061a
    Figure 1: Western blot analysis using Akt3 mouse mAb against truncated Akt3 recombinant protein (1) and human ovary carcinoma tissue lysate (2).
  • IHC - Akt3 Antibody AO1061a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human skin carcinoma (left) and pancreas carcinoma (right) tissue, showing cytoplasmic localization using EphA2 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y243
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3B12F3F10; 2D2B11B11; 2D2B11H5
Calculated MW 55775 Da
Description Akt3 (also designated protein kinase B gamma or v-akt murine thymoma viral oncogene homolog 3),with 479-amino acid protein (about 53kDa), belongs to the AKT serine/threonine protein kinase family, which also includes Akt1 and Akt2. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake.Akt3 is not required for the maintenance of normal carbohydrate metabolism but is essential for the attainment of normal organ size. Identifying Akt3 as a selective target in melanoma cells also provides new therapeutic opportunities for patients in the advanced stages of this disease.
Immunogen Purified recombinant fragment of Akt3 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 10000
Other Names RAC-gamma serine/threonine-protein kinase,, Protein kinase Akt-3, Protein kinase B gamma, PKB gamma, RAC-PK-gamma, STK-2, AKT3, PKBG
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAkt3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AKT3
Synonyms PKBG
Function AKT3 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis.
Cellular Location Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation
Tissue Location In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney
Research Areas
Citations (0)

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1. Rachael M. Easton, Han Cho, Kristin Roovers. Mol. Cell. Biol., Mar 2005; 25: 1869 – 1878 2. Jill M. Stahl, Arati Sharma, Mitchell Cheung. Cancer Res., Oct 2004; 64: 7002–7010

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$ 385.00
Cat# AO1061a
(40 western blots)
Availability: 7-10 days
Bulk Size
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